[zLucifer]

Try running the program as Administrator. If that doesn't work, check that your gta_sa.exe is executing in the correct place, if you have moved your gta_sa.exe, then your SAMP.exe cannot execute gta_sa.exe, instead of moving them from Program Files, put them back, and use 'Create Shortcut' function instead. If this suggestion doesn't work, re-install GTA SA & SAMP.