[Si|ent]

Until you find whats causing it (usually mods if you are crashing hard)
Before you play CTRL-ALT-DEL to bring up Task Manager.
Make sure it is on Applications tab
Close it, close all other applications. Run SAMP
If and when you crash do the following (you will be operating blind, due to SA being 'stuck' on your screen.

CTRL-ALT-DEL, then TAB, then space, then space

(This brings up task manager again, selects End task on GTASA and agrees to close it)

That should get you back to your desktop without the need to restart